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Home Antibody All anti-TGIF1 antibodies

Anti-TGIF1 Antibody EP637Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300819
  • Rabbit Monoclonal Antibody against TGIF1 (Clone EP637Y)
100ul 325 In Stock
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WB(1)
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Also for TGIF1 (NM_174886)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human TGIF was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated TGIF.
Clone NameEP637Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1: 1000; IP: 1:30
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens TGFB-induced factor homeobox 1 (TGIF1), transcript variant 8
Alternative NameHPE4; TGIF
Database LinkNP_777480
FunctionNovel homeobox gene, denoted TGIF (5"TG3' interacting factor), belongs to an expanding TALE (three amino acid loop extension) superclass of atypical homeodomains. The TGIF homeodomain binds to a previously characterized retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE), which contains an unusual DNA target for a homeobox (1). In vitro studies have implicated TGIF as a transcriptional repressor and corepressor in retinoid and TGF-beta signaling pathways that regulate several important biological processes. Heterozygous nonsense and missense mutations of the human TGIF gene have been associated with holoprosencephaly, the most common congenital malformation of the forebrain (2). It has been reported that TGIF plays an unexpected role in the inhibition of Smad2 phosphorylation, which occurs by a mechanism independent of its association with Smad2. This inhibitory function of TGIF is executed in concert with c-Jun, which facilitates the interaction of TGIF with cPML, resulting in the nuclear sequestration of cPML and the disruption of the cPML-SARA complex (3).
Related Pathway
EGFR1 Signaling Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot - TGIF antibody [EP637Y]; Anti-TGIF antibody [EP637Y] at 1/1000 dilution + K562 cell lysate at 10 µg.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 45 kDa.Observed band size : 30 kDa .

 

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