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Anti-MMP3 Antibody EP1186Y
Also for MMP3 (NM_002422)
|A synthetic peptide corresponding to residues near the C-terminus of human MMP-3 was used as an immunogen|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3)|
|CHDS6; MMP-3; SL-1; STMY; STMY1; STR1|
Entrez Gene 4314 Human
Entrez Gene 17392 Mouse
Entrez Gene 171045 Rat
|Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, and arthritis (1). Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. MMP3 (stromelysin) is a secreted metalloprotease with a wide range of substrate specificities. MMP3 is synthesized in a preproenzyme form with a calculated size of 54 kDa and a 17-amino acid long signal peptide. Data indicate that the expression and the possible involvement of secreted metalloproteases in tumorigenesis result from a specific interaction between the transforming factor and the target cell, which may vary in different species (2). In neural studies, matrix metalloproteinase-3 (MMP-3) was newly induced and activated in stressed dopamine cells, and the active form of MMP-3 (actMMP-3) was released into the medium. The released actMMP-3, as well as catalytically active recombinant MMP-3 (cMMP-3) led to microglial activation and superoxide generation in microglia and enhanced DA cell death. (3). |
|ProteaseDruggable Genome |
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Western blot - MMP3 antibody [EP1186Y]; Anti-MMP3 antibody [EP1186Y] - Carboxyterminal end at 1/1000 dilution + Recombinant protein (0.5ng).Secondary.Goat anti-Rabbit HRP labeled at 1/2000 dilution.Predicted band size : 54 kDa.Observed band size : 50 kDa .
Immunohistochemistry (Paraffin-embedded sections) - MMP3 antibody [EP1186Y]; Ab52915 (1:100) staining human MMP3 in human gastric carcinoma tissue by immunohistochemistry using paraffin embedded tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP3 antibody [EP1186Y] - Carboxyterminal end; Immunohistochemical analysis of rat spinal tissue, staining MMP3 with TA300812. Sections were incubated with primary antibody in 2% BSA in PBS at a dilution of 1/250 overnight at 4°C. An AlexaFluor?488-conjugated anti-rabbit IgG (1/100) was used as the secondary antibody.