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Home Antibody All anti-AURKC antibodies

Anti-AURKC Antibody EP1011Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300719
  • Rabbit Monoclonal Antibody against AURKC (Clone EP1011Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC423127) , 20ug
100ul $325 3-7 Days
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WB(1)
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Also for AURKC (NM_001015878)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human Aurora C was used as an immunogen.
Clone NameEP1011Y IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1: 1000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens aurora kinase C (AURKC), transcript variant 1
Alternative NameAIE2; AIK3; ARK3; AurC; aurora-C; SPGF5; STK13
Database LinkNP_001015878
FunctionAurora-C is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Studies show that human Aurora-C is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins. INCENP binds and activates Aurora-C in vivo and in vitro. Aurora-C co-expressed with INCENP elicits the phosphorylation of endogenous histone H3 in mammalian cells, even though this phosphorylation is not sufficient to establish chromosome condensation in interphase cells (2). Over-expression of an inactive mutant of Aurora C impaired the localization of Aurora C to the spindle midzone resulting in multinucleation which demonstrates that Aurora C is required for cytokinesis (3).
Related Pathway

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WB Image
Western blot - IPL-1/STK13/Aurora C antibody [EP1011Y] - Aminoterminal end; Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] - Aminoterminal end at 1/1000 dilution + HepG2 lysate at 10 µg.Secondary.goat anti rabbit HRP at 2000 .Predicted band size : 36 kDa.Observed band size : 36 kDa.

 

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