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Anti-AURKC Antibody EP1011Y
Also for AURKC (NM_001015878)
|A synthetic peptide corresponding to residues near the N-terminus of human Aurora C was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1: 1000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens aurora kinase C (AURKC), transcript variant 1|
|AIE2; AIK3; ARK3; AurC; aurora-C; SPGF5; STK13|
Entrez Gene 6795 Human
|Aurora-C is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Studies show that human Aurora-C is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins. INCENP binds and activates Aurora-C in vivo and in vitro. Aurora-C co-expressed with INCENP elicits the phosphorylation of endogenous histone H3 in mammalian cells, even though this phosphorylation is not sufficient to establish chromosome condensation in interphase cells (2). Over-expression of an inactive mutant of Aurora C impaired the localization of Aurora C to the spindle midzone resulting in multinucleation which demonstrates that Aurora C is required for cytokinesis (3). |
|Protein KinaseDruggable Genome |
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Western blot - IPL-1/STK13/Aurora C antibody [EP1011Y] - Aminoterminal end; Anti-IPL-1/STK13/Aurora C antibody [EP1011Y] - Aminoterminal end at 1/1000 dilution + HepG2 lysate at 10 ug.Secondary.goat anti rabbit HRP at 2000 .Predicted band size : 36 kDa.Observed band size : 36 kDa.