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Home Antibody All anti-AURKA antibodies

Anti-AURKA Antibody EP1008Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300714
  • Rabbit Monoclonal Antibody against AURKA (Clone EP1008Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403678) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for AURKA (NM_198433)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human Aurora-A was used as an immunogen.
Clone NameEP1008Y IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:50,000; IHC: 1: 100-250; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens aurora kinase A (AURKA), transcript variant 1
Alternative NameAIK; ARK1; AURA; AURORA2; BTAK; PPP1R47; STK15; STK6; STK7
Database LinkNP_940835
FunctionAurora-A is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Aurora-A is ubiquitously expressed and activated through an interaction with Ajuba and TPX2 during late G2 and mitotic phases. Activated form regulates the functions of centrosomes, spindles, and kinetochores required for normal mitotic progression. Initially localized at centrosome during interphase, Aurora-A is translocated to mitotic spindles in early mitotic phase and finally degraded after metaphase–anaphase transition (2). Overexpression of Aurora-A is seen various tumors, where an overexpression can induce abnormalities in G2 and Spindle checkpoints, and cytokinesis failure (3).
Related Pathway
Cell cycle

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Aurora A antibody [EP1008Y]; Anti-Aurora A antibody [EP1008Y] at 1/50000 dilution + HepG2 cell lysate at 10 µg.Secondary.goat anti-rabbit HRP labelled at 1/2000 dilution.Predicted band size : 46 kDa.Observed band size : 46 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Aurora A antibody [EP1008Y]; TA300714, at a 1/100 dilution, staining Human Aurora-A in Cervical Carcinoma using Immunohistochemistry, Paraffin Embedded tissue. Bottom pannel is a larger magnification of the above image.

 

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