OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-MUC1 antibodies

Anti-MUC1 Antibody EP1024Y

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300711
  • Rabbit Monoclonal Antibody against MUC1 (Clone EP1024Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400880) , 20ug Explanation
100ul 325 In Stock
Add to Shopping Cart
spacer
WB(1)
IHC(2)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human MUC1 was used as an immunogen.
Clone NameEP1024Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; WB: 1:1000 - 1:10000; IHC-P: Use at an assay dependent dilution; FC: 1:30; IP: 1:50
Predicted MW Explanation 22 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC/IF.

Reference Data

Target NameHomo sapiens mucin 1, cell surface associated (MUC1), transcript variant 1
Alternative NameADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC;
Database LinkNP_002447
Entrez Gene 4582 Human
Entrez Gene 17829 Mouse
Entrez Gene 24571 Rat
FunctionMucins are high molecular weight glycoproteins that provide a protective layer on epithelial surfaces and are involved in cell-cell interactions, signaling, and metastasis. MUC1 consists of an extracellular subunit and a membrane-associated subunit (1). The two moieties are produced from a single precursor polypeptide by an early proteolytic cleavage event but remain associated throughout intracellular processing and transport to the cell surface. It has been shown that MUC1 expression inhibits erbB1 (regulators of cell survival and growth) degradation and also E-cadherin (2). Isoform 7 of MUC1 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling (3).
Related PathwaySecreted ProteinTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - MUC1 antibody [EP1024Y]; Anti-MUC1 antibody [EP1024Y] at 1/1000 dilution + T47D cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP labelled, at 1/2000 dilution.Observed band size : 22 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - MUC1 antibody [EP1024Y]; Ab45167 at a 1/100 dilution, staining human MUC1 in human breast carcinoma by immunohistochemistry using paraffin embedded tissue.
IHC Image
Immunohistochemistry (Frozen sections) - Anti-MUC1 antibody [EP1024Y]; Ab45167 staining MUC1 on E14.5 mouse gut epithelium by IHC-Fr. The tissue was formaldehyde fixed and then blocked for 1 hour at 25°C. The primary antibody was diluted 1/400 and incubated with the sample for 16 hours at 4°C. An Alexa Fluor 488 conjugated goat anti-rabbit antibody was used as the secondary.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title