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Anti-TP73 Antibody EP436Y


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SKU Description Amount Price Availability*  
TA300559 Rabbit Monoclonal Antibody against TP73 (Clone EP436Y) 100ul $325 In Stock
LC417321 TP73 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the transactivation domain of human p73 was used as immunogen. p73 has a predicted molecular weight of 73 kDa but is detected at 63kDa.
Clone NameEP436Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; WB: 1:500 - 1:2000; ICC/IF: 1:150; IHC-P: Use at an assay dependent concentration
Predicted MW Explanation 70 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens tumor protein p73 (TP73), transcript variant 1
Alternative NameP73
Database LinkNP_005418
Entrez Gene 7161 Human
Entrez Gene 362675 Rat
Functionp73 is a transcription factor that shares a significant amino acid identity with p53 and p63 (1). p73 and p63 can both activate p53-responsive genes and induce apoptosis upon over- expression (2) Unlike p53, p73 is not induced by DNA damage and is not a target for inactivation by viral oncoproteins (3). Similar to p63, p73 has an additional coding region in the C-terminus (not found in p53) that can undergo complex alternative splicing giving rise to 3 splice forms (a, ß, and ?) (4). Activation of p73 requires the presence of functional c-Abl. It has also be found that mutant p53 can bind to and inactivate p73 (5).
Related PathwayTranscription FactorsDruggable Genome p53 signaling pathwayNeurotrophin signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - p73 antibody [EP436Y]; All lanes : Anti-p73 [EP436Y] antibody at 1/2000 dilution.Lane 1 : Hela lysate.Lane 2 : Jurkat lysate.Lane 3 : NIH 3T3 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 70 kDa.Observed band size : 63 kDa .
Immunohistochemistry (Paraffin-embedded sections) - p73 antibody [EP436Y]; Immunohistochemical analysis of paraffin-embedded human urinary bladder carcinoma using 1/100 TA300559
Immunohistochemistry (Frozen sections) - p73 antibody [EP436Y]; TA300559 staining p73 in murine hairy skin tissue by Immunohistochemistry (Frozen sections).Tissue was fixed with paraformaldehyde, permeabilized using 0.1% Triton then blocked using 5% BSA for 30 minutes at 25°C. Samples were then incubated with TA300559 at a 1/100 dilution for 16 hours at 25°C. The secondary used was an Alexa-Fluor 488 conjugated goat anti-rabbit polyclonal used at a 1/1000 dilution.


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