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Home Antibody All anti-RPS6KA1 antibodies

Anti-RPS6KA1 Antibody E239

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300415
  • Rabbit Monoclonal Antibody against RPS6KA1 (Clone E239)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401035) , 20ug
100ul 325 3-7 Days
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WB(2)
IF(1)
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Also for RPS6KA1 (NM_002953)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Ser380 of human p90RSK1 was used as immunogen. The antibody only detects RSK1 phosphorylated on Serine 380.
Clone NameE239 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1: 10,000; ICC: 1:250-500; IP: 1:80
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction

Reference Data

Target NameHomo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1
Alternative NameHU-1; MAPKAPK1A; RSK; RSK1
Database LinkNP_002944
FunctionRSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
Related Pathway
EGFR1 Signaling Pathway
MAPK signaling pathway

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WB Image
Western blot - RSK1 p90 (phospho S380) antibody [E239]; All lanes : Anti-RSK1 p90 (phospho S380) antibody [E239] at 1/10000 dilution.Lane 1 : A431 cell lysate, untreated.Lane 2 : A431 cell lysate, treated with EGF .Predicted band size : 83 kDa.Observed band size : 90 kDa .
WB Image
Western blot - Anti-RSK1 p90 (phospho S380) antibody [E239]; .Predicted band size : 83 kDa.Image from Tangredi MM et al., J Biol Chem. 2012 May 11;287(20):16748-58. Epub 2012 Mar 23.; Fig 4.; doi: 10.1074/jbc.M111.315929; May 11, 2012, The Journal of Biological Chemistry, 287, 16748-16758.
IF Image
Immunocytochemistry/ Immunofluorescence - RSK1 p90 (phospho S380) antibody [E239]; Immunofluorescent staining of A431 cells using TA300415 at 1/250 dilution.

 

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