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Home Antibody All anti-CHEK1 antibodies

Anti-CHEK1 Antibody E250

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300392
  • Rabbit Monoclonal Antibody against CHEK1 (Clone E250)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400510) , 20ug
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to N-terminal residues of human Chk1 was used as immunogen.
Clone NameE250 IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1: 1,000; ICC: 1:50; IP: 1:80
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction

Reference Data

Target NameHomo sapiens checkpoint kinase 1 (CHEK1), transcript variant 3
Alternative NameCHK1
Database LinkNP_001265
FunctionChk1 is involved in cell cycle arrest when DNA damage has occurred, and it plays an important role in DNA damage checkpoint, embryonic development and tumor suppression (1). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (2). Activated Chk1 can bind to, phosphorylate (at serine 216) and inactivate cdc25c (3,4 ). Phosphorylation of cdc25c prevents activation of the CDC2-cyclin B complex and prevents entry into M-phase (3, 4).
Related Pathway
Cell cycle

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WB Image
Western blot - Chk1 antibody [E250]; Anti-Chk1 antibody [E250] at 1/1000 dilution + K562 cell lysate.Predicted band size : 54 kDa.Observed band size : 54 kDa.

 

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