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Anti-CASP8 Antibody E6
Also for CASP8 (NM_033355)
|A synthetic peptide corresponding to N-terminal residues of human Caspase-8 was used as immunogen. The antibody should recognize all splice isoforms of Caspase-8.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:3000; IHC-P: Use at an assay dependent dilution; FC: 1:50; IP: 1:50
|Does not react with Mouse, Rat. Is unsuitable for ICC.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for ICC.
|Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant B|
|ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5|
|Caspase-8 (MACH/FLICE/Mch5) is a member of a family of cysteine-requiring aspartate proteases that participate in the intracellular signaling cascade leading to apoptosis, or programmed cell death (1-4). Caspase-8 is recruited to death-inducing signaling complex (DISC) CD95 (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) and is subsequently activated by proteolytic cleavage into two residues, p10 and p18 (1-4). Active caspase-8, the first in the caspase signaling cascade, signals downstream caspases to eventually induce apoptosis.|
MAPK signaling pathway
Toll-like receptor signaling pathway
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Western blot - Caspase 8 antibody [E6]; Anti-Caspase 8 antibody [E6] at 1/3000 dilution + Jurkat cell lysate.Predicted band size : 55 kDa.Observed band size : 55 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Caspase 8 antibody [E6]; Immunohistochemical analysis of Caspase 8 expression in paraffin embedded human breast adenocarcinoma tissue section using 1/100 ab32125.