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Also for DIO2 (NM_000793)
|Peptide with sequence EVKKHQNQEDRC, from the internal region of the protein sequence according to NP_000784.2; NP_054644.1; NP_001007024.1.|
|Test: Mouse. Expected from seq similarity: Human, Mouse, Rat, Pig
|0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
|Homo sapiens deiodinase, iodothyronine, type II (DIO2), transcript variant 2|
|5DII; D2; DIOII; SelY; TXDI2|
Entrez Gene 1734 Human
Entrez Gene 13371 Mouse
Entrez Gene 65162 Rat
|The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].|
|Druggable Genome |
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TA305836 (2ug/ml) staining of PFA-fixed cryo-sectioned Mouse Hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining.