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Also for STIM1 (NM_003156)
|STIM1 antibody was raised against a 24 amino acid peptide from near the carboxy terminus of human STIM1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens stromal interaction molecule 1 (STIM1), transcript variant 2|
|D11S4896E; GOK; IMD10; STRMK; TAM; TAM1|
Entrez Gene 6786 Human
Entrez Gene 20866 Mouse
Entrez Gene 361618 Rat
|In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least two isoforms of STIM1 are known to exist; this antibody will detect only the larger form. This STIM1 antibody is predicted to have no cross-reactivity to STIM2.|
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Western blot analysis of STIM1 in mouse thymus tissue lysate with STIM1 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of STIM1 in human spleen tissue with STIM1 antibody at 2.5 ug/ml.
Figure from citation: Immunohistochemistry of STIM1 protein level by using anti-STIM1 antibody in muscle type II fibers in Stormorken syndrome patients. Dilution: 1:200 View Citation