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Also for HSD11B1 (NM_181755)
|Synthetic peptide corresponding to a region within amino acids 232 and 292 of HSD11B1|
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 2|
|11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1|
Entrez Gene 3290 Human
|The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]|
|TransmembraneDruggable Genome C21-Steroid hormone metabolismAndrogen and estrogen metabolismMetabolic pathways|
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Sample (30 ug of whole cell lysate). A: Hep G2 . 12% SDS PAGE. TA308504 diluted at 1:1000.
HSD11B1 antibody detects HSD11B1 protein at cytosol on hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded hepatoma. HSD11B1 antibody (TA308504) dilution: 1:500.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using HSD11B1(TA308504) antibody at 1:200 dilution.