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|Recombinant fragment corresponding to a region within amino acids 209 and 449 of Wilms Tumor 1 (Uniprot ID#P19544)|
||Lot dependent; please refer to CoA along with shipment
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens Wilms tumor 1 (WT1), transcript variant C|
|AWT1; GUD; WAGR; WIT-2; WT33;GUD; WAGR; WIT-2; WT33; Wilms tumor 1|
Entrez Gene 7490 Human
|This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq]|
|Transcription FactorsDruggable Genome |
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Wilms Tumor 1 antibody detects Wilms Tumor 1 protein at nucleus and cytosol on mouse testis by immunohistochemical analysis. Sample: Paraffin-embedded mouse testis. Wilms Tumor 1 antibody (TA308577) dilution: 1:500.