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Also for PSAP (NM_001042465)
|Recombinant fragment corresponding to a region within amino acids 1 and 250 of PSAP (Uniprot ID#P07602)|
|Human (Predicted: Pig)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Pig (87%)
|Homo sapiens prosaposin (PSAP), transcript variant 2|
Entrez Gene 5660 Human
|This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]|
|Druggable Genome Lysosome|
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Sample (30 ug of whole cell lysate). A: Molt-4 . 7.5% SDS PAGE. TA308630 diluted at 1:2000.
Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft , using PSAP(TA308630) antibody at 1:500 dilution.